Currently Published Papers in Green Chemistry

Therapeutic effect of Portulace Olerecea leaves and seeds against hypercholesterolemia induced in rats.

Afaf O. Ali and Nivin S.Nail

The objective of this study was to investigate the effect of dried leaves and seeds of purslane (Portulace Olerecea) on lipids levels in experimentally induced hypercholesterolemic rats. Thirty six male Albino rats were divided into 6 groups and reared for 1.5 months. The groups were: group (1) control, group (2) fed hypercholesterolemic diet (positive control), group (3) fed 10% grounded seed of Portulace Olerecea, group (4) fed  10% grounded leaves of Portulace Olerecea, group (5) hypercholesterolemic rats fed 10% grounded Portulace Olerecea seeds, group (6) hypercholesterolemic rats fed 10% grounded Portulace Olerecea leaves. At the end of experimental period, all rats were scarified and blood samples were taken for determination of liver function aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) ,and lipid profile( triglyceride TG, cholesterol TC and high density lipoproteins HDL) determination. Also the fecal cholesterol and TG were determined. Liver and heart were taken for pathology analysis. The results showed that liver function activities (ALT, AST and ALP) were significantly decreased in the groups fed on 10% Portulace Olerecea seeds (gp.5) or leaves (gp.6) compared to the hyper-cholesterol group (gp.2). The levels of serum TG, TC were decreased in the group fed on 10% Portulace Olerecea seeds (gp.5) more than the group fed on 10% Portulace Olerecea leaves (gp.6) and both were better than hypercholesteralmic group (gp.2).While the HDL level was increased for both groups of Portulace Olerecea leaves or seeds compared to hypercholestolmic group which decreases in HDL. Fecal TC and TG levels were higher in groups fed 10% Portulace Olerecea leaves (gp.5) or seeds (gp.6) than hypercholesterolmic group (gp.2). Liver and heart histopathology showed more improvement in cell structure in groups fed Portulace Olerecea. The data also revealed that there is an improvement in lipid profile and lipid level discharged in the feces which suggested that Portulace Olerecea seeds reduces lipid in hypercholesteralmic rats and work as hepatoprotective by improving liver function more than leaves compared with high fat group.

Studies on Synthesis of Aromatic Schiff Bases. Part-III. Synthesis, Characterization and Biological Potential of Novel Ketimines from 5-Chloro-2-hydroxy-4-methyl-acetophenone with substituted anilines

C. J. Patil, Manisha C. Patil and Mrunmayee C. Pati

The rare aromatic ketone, 5-Chloro-2-hydroxy-4-methyl-acetophenone condensed with aniline and its six dialkyl derivatives viz. 2,3-Dimethyl-aniline, 2,4-Dimethyl-aniline, 3,4-Dimethyl-aniline, 2,5-Dimethyl-aniline, 2,6-Dimethyl-aniline, and 3,5-Dimethyl-aniline(each separately) efficiently to produced a series of novel ketimines, CJ-0 to CJ-6. These were analyzed by employing the techniques such as thin layer chromatography(TLC) and UV-Vis spectra. All these novel ketimines were characterized by their colour, physical constant, TLC, elemental analysis and spectral(UV-Vis and FTIR) methods. After confirming their desired molecular studies, these novel ketimines were studied for their biological potential.

Coupling Reactions Involving Reactions of Aryldiazonium Salt: Part-VI. Chemoselective Condensation of Aryldiazonium Salt with Resorcinol

C. J. Patil, G. P. Waghulde and Mrunmayee C. Patil

The aryldiazonium salt is used as intermediate in different reactions because, Ar-N2ÅClare highly reactive compounds. These reactions, either, losses nitrogen containing function or without loss of nitrogen function. In the present piece of work we have reacted the five aryldiazonium salt with phenolic compound(Resorcinol). The final product, 1 to 5 formed has potential to use as azo dyes and as intermediate in other synthetic procedures or transformations.">

Use of Leucaena Leucocephala

Hemlata Raikwar and Dr. Anita Chowbey

Leuceana lucocephala is a small tree originated and scoped as a weed in tropical and warm temperate region of other countries in India .it mostly cultivated for its fodder fuel, timer and other important uses like huge plant, green manure, food for animal and like a bio energy crop. Leucaena Leucocephala, commonly called subabul in the locality of Vidisha district, has considered for crop intensification .Leucaena Leucocephala has also considered among the fast-growing, multipurpose nitrogen-fixing trees, hence, it has  regarded by  the nickname “Miracle tree”. In recent years, subabul has become popular among farmers in the southern states also due to its ability to produce pulpwood within a three to five years. on this basis, leucaena  leucocephala was selected as potential pulping raw material and alternative source fiber for making the paper. The Leuceana Leucocephala plant has high nutritive content like carbohydrats, protein and fat as alfalfa.it is used as a raw material for making paper, agriculture implements and the seed oil could be used as biofuel by blending with the conventional diesel.

Green Chemistry: An Efficient Synthesis and Antimicrobial Activity of Disubstituted 3,4-dihydro-2H-1,3-thiazin-4-ones

Esam A. Ishak, Tamer El Malah and H. M. A. Abdelzaher

An efficient and greener approach has been developed for the Synthesis of 6-arylamino-5-cyano-2, 3-dihydro-1,3-thiazin-4(1H)-ones, using Lemon juice as a natural catalyst. It was prepared via condensation of 3-arylamino-2-cyano-3-mercaptoacrylamides with various of aldehydes. The reaction proceeded in short period of time with excellent yields  All the synthesized compounds were evaluated for their anti-bacterial and antifungal activities.