Currently Published Papers in Herbal Chemistry

Radical scavenging activity of Pisonia alba leaves in different extracts

Kavitha Rani M and Suriyavathana M,IJGHC, June 2018 – August 2018; Sec. B; Vol.7, No.3, 320-327,DOI: 10.24214/IJGHC/HC/7/3/320-327

Research on natural drugs has popularity due to base on discovering of bioactive compound. The antioxidant property present in the plants are one of the mechanism to observe the effect of plant compound. Antioxidant are capably to reduce the free radical effect which consist of singlet electron on the shell. Pisonia alba plant belongs to Nyctaginaceae family had the abundant healing property. This study aim to elaborate the radical scavenging activity (RSA) of Pisonia alba leaves extract. The RSA was assessed with three different extractions (ethanol, methanol and aqueous) by 5 different methods at various concentration (20 – 100 μg/ml): DPPH, FRAP, Superoxide radical, Nitric oxide and Reducing power, Vitamin C (ascorbic acid) used as positive control. ELEPA showed the RSA power when compared with MLEPA and ALEPA. The Percent inhibition scavenging activity of ELEPA with ascorbic acid on various RSA viz of DPPH at 91±2.7 at 100 μg/ml; 90±2.2 μg/ml in FRAP; 89±2.1 μg/ml in Nitric oxide; 79±2.1 at100 μg/ml in superoxide; absorbance at 700nm in reducing power 0.721±0.015). Among the three fractions ELEPA has lowest IC50 value which strongly represents the highest scavenging power.

Clinical Comparative Study on Efficacy of Gudadya Gutika and Punarnava Mandura in Iron Deficiency Anaemia W.S.R. Pandu

Vinaya Vishnumurthy Yaji, Vijay B. Negalur, SandeshKumar, Nagraj G Bhat.,IJGHC, June 2018 – August 2018; Sec. B; Vol.7, No.3, 309-319.DOI: 10.24214/IJGHC/HC/7/3/30919

To study the concept of Nutritional iron deficiency anemia w.s.r. Pandu.To evaluate the effect of Gudadyagutika in Nutritional iron deficiency anaemiaw.s.rPandu. To compare the effect of Gudadyagutika and PunarnavaMandura in Nutritional iron deficiency anaemiaw.s.r. Pandu. Single blind controlled comparative study with pre-test and post-test design. 40 subjects of iron deficiency anemia fulfilling the diagnostic and inclusion criteria were selected from the OPD and IPD of S.D.M. Ayurveda College and Hospital Udupi. Data is collected based on subjective and objective criteria of the study.Group A-In this group Gudadyagutika is administered to patients with the dose of 2-0-2 after food with anupanasukhoshnajalafor 45 days.Group B-Patients of this group given Punarnavadimandura 2-0-2 after food with anupanatakrafor 45 days.Both groups shows improvements in subjective and objective parameters, when compared, Group1 (Gudadyagutika) shows better improvements than compare to Group 2(Punarnavamandura) with statistically highly significant results in subjective and objective parameters. In this study it has shown better result in improving the Objective parameters like Haemoglobin% and improvement in decreasing the values of lymphocytes, eosinophils and in subjective parameters- improvement seen in Mandagni (reduced appetite), Durbalata(weakness), Shrama(tiredness), Pindikodvesta, Exertional dyspnoea, General fatigue, Skin pallor, Headache, Insomnia.

An Ethnobotanical Survey of Indigenous Medicinal Plants in Sarguja District, Chhattisgarh (India)

Dr. Mantosh Kumar Sinha,IJGHC, June 2018 – August 2018; Sec. B; Vol.7, No.3, 301-308.DOI: 10.24214/IJGHC/HC/7/3/30108

Surguja district lies in the northern part of Chhattisgarh state is biodiversity rich area, dominated by tribal communities. The major tribes of Surguja region are Nagesiya, Baiga, Kanwar, Panika, Korwa and Uraon. Uraon is one of the dominating populations amongst all the tribes found in Surguja. In Surguja, the tribal's are 55.4% of the total population. The total forest area in the region is 18,188.44 constitute 44% of the total area of the district. Recently Ethnomedicinal studies have gained importance during recent years. However, this valuable source of knowledge is not adequately documented,which impedes their widespread use, evaluation and validation.Here,in the present work selected medicinal plant species, used extensively by local people and tribal communities residing in Surguja district have been screened qualitatively to find out their ethno medicinal properties. These plants are commonly used in vomiting, diarrhea, ringworm, ear pain, gastric problem, stone, infertility, diabetes and blood pressure, Bone fracture, Bad Breath Bronchitis, Body pain, Burns, Blood Cancer, Cough, etc. The present work listing includes botanical name, family and ethno medicinal uses of some plants. This work highlights updated information that may provide incentive for proper evaluation of the plants medicinal agent against many human diseases.

Antihyperglycemic and Antihyperlipidemic Moderating Effect of Catharanthus roseus Sadabahar) Leaves in Type II Diabetic Mellitus Subjects

K. Sharma, Akansha, S. Choudhary, E.S. Chauhan,IJGHC, March 2018 – May 2018;DOI: 10.24214/IJGHC/HC/7/2/23947. Sec. B; Vol.7, No.2, 239-247.

Diabetes mellitus is one of the well-known significant disorders of the endocrine system. It is characterized by an abnormal increase in the glucose load. Catharanthus roseus is an important Ayurvedic medication in traditional medicine. It is potentially used in countries like India, South Africa, China and Malaysia for the healing of diabetes mellitus. Due to the great antidiabetic and hyperlipidemic potential of Catharanthus roseus, we hypothesized that the effect of leaves powder shows a significant decrease in the blood glucose and lipid levels. The first group treated with leaves powder of Catharanthus roseus 75mg/100g incorporated in baked khakre. The biochemical evaluations of blood sample of subjects were done. The blood samples were taken using glucometer. The proposed study was framed to look at the antidiabetic and antihyperlipidemic efficacy of leaves powder of Catharanthus roseus. The doses were administered at a rate of 75mg/100g incorporated in baked khakre and detrained the glucose transport system in 8 weeks. We conclude that there is a significant decrease in blood glucose and lipid parameters. The findings are very encouraging and greatly advocate its candidature for the design of a novel herbal drug to cure deadly diabetes

Phytochemical Screening and Antimicrobial Activity of Methanol Extract of Microtrichia Perotitii DC (Asteraceae) against Selected Micro-Organisms

Abdullahi, M. N .and Mustapha, A. O. ,IJGHC, March 2018 – May 2018; Sec. B; Vol.7, No.2, 230-.238,DOI: 10.24214/IJGHC/HC/7/2/23038

The resistance of micro-organisms against synthetic drugs has drawn the attention of the world to look for alternatives from plants (herbs). Microtrichia perotitii (Asteraceae) is an herb that can be exploited most especially since not much studies have been reported on it despites its uses for treating pain related diseases. In this study the phytochemical contents and anti-microbial properties of the herb were investigated. The herb was collected from Okene in Kogi State, Nigeria and was authenticated, prepared and extracted with methanol following standard methods. The preliminary phytochemical screening was carried out according standard protocols while antimicrobial screening was performed according to agar diffusion method as modified on hospital isolates of the species of streptococcus, staphylococcus, Escherichia coli, shigella and candida. The phytochemical screening of the methanol extract revealed the presence of alkaloids, flavonoids, tannins, saponins, terpenoids and cardiac glycosides while phlobatannins and anthraquinones were not detected. Tannins, flavonoids and alkaloids are compounds with anti-microbial activities. Hexane, ethylacetate and methanol soluble fractions showed highest susceptibility against the species of streptococcus, Escherichia coli and only ethylacetate and methanol suppressed the growth of candida species. The methanol extract of Microtrichia perotitii possesses antimicrobial activity which could be described as antibacterial and antifungal owing to the type of phytocompounds present. Thus, Microtrichia perotitii represents a promising source of antibiotics as well enormous therapeutic potentials. This research is the first time it would be reported for Microtrichia perotitii.