Currently Published Papers in Herbal Chemistry

Study of Antioxidant and Aldose Reductase Inhibitory Activity of a weed, Hygrophila ringens (L.) R. Br. ex (Steud.)

T. V. Ramana, O. S. Rathor1,G. Gyananath, Zeyad A. Dahan, G. B. Tiwari4, T.A. Kadam, DOI: 10.24214/IJGHC/HC/7/3/34759

Bioprospecting involves exploration of unidentified species of living organisms for the development of pharmaceuticals, botanical medicines, crop protection agents, cosmetics, horticultural and agricultural seeds, environmental monitoring, manufacturing and construction. With the popularity of bioprospecting for natural compounds, the idea is to elaborate the various chemical components on one of the uncommon plant, Hygrophila ringens (L.) R. Br. ex (Steud.) Acanthaceae family from Marathwada region. In the current study, the phytochemical components were screened in the leaves, flowers and stem of Hygrophila ringens (L.). The analysis revealed  presence of  diverse class of  compounds of therapeutic significance and as speculated the plant extracts exhibited potent antioxidant and ARI activity.  Some of the potential phytochemical compounds may have an important role in these activities.

Harnessing the medicinal importance of Clitoria ternatea for diseases and beyond: a review of its phytochemistry and pharmacology

K. Sharma, R. Bist and ES. Chauhan,DOI: 10.24214/IJGHC/HC/7/3/33646

Clitoria ternatea L generally recognized as Butterfly pea is a traditionally being used Ayurvedic medicine. It is being utilized from centuries to enhance memory and as nootropic, anti-stress, as tranquilizer to relieve anxiety, depression, and convulsion. C. ternatea isolated secondary metabolites include triterpenoids, flavonol glycosides, anthocyanins. It possesses extensive variety of pharmacological actions like fighting against microorganisms, reducing fever, alleviating inflammation and pain, promoting diuresis, controlling diabetes and destroying insects. It is also used as a vascular smooth muscle relaxant. The current review encompasses the bio-active components, pharmacological, phytochemical and toxicity studies of C. ternatea having clinical usage in the Ayurvedic system along with a serious consideration on its future ethno pharmacological potential

Identification of Novel Metabolites and Screening of Antimicrobial and Anti-mycobacterium tuberculosis Activity of Bauhinia Purpurea Flowers

P. Sarojini, K. Shriram, M. Jeyachandran ,V. S. Krishna and D. Sriram,DOI: 10.24214/IJGHC/HC/7/3/32835

Bauhinia purpurea is a significant herb with prodigious nutritional and medicinal value. Research on its secondary metabolites and biological activities of antimicrobial, analgesic, anti-inflammatory, antidiabetic, anticancerous, anti-diarrheal and nephroprotective activity has been boundless. In the present study, the flowers of Bauhinia purpurea were exhaustively extracted with aqueous ethanol and the solvent was removed to get crude extract and it was found to be a mixture of components by TLC. The extract was analyzed for primary phytochemical tests and GCMS studies to find out the nature of compounds present in it. The occurrence of steroids, reducing sugars, saponins, xanthoproteins, tannins and flavonoids were identified from the primary phytochemical tests. From the GCMS studies, four new compounds Pelargonyl acetate, Kaempferol 3, 7-dimethyl ether, γ-Terpinene and β-Linalool were identified   from the Bauhinia purpurea flower. Furthermore, fifteen known compounds 5-Methoxy-3, 7-dihydroxyflavanone, 5-Methoxy-3, 7-dihydroxyflav- anone, Lutein and Glaucine etc., were also obtained from the above extract. The crude extract was evaluated for antimicrobial and antimycobacterium tuberculosis activity, which possessed pronounced antimicrobial and prominent antimycobacterial tuberculosis activity at 2.25 MIC µg/mL.

Radical scavenging activity of Pisonia alba leaves in different extracts

Kavitha Rani M and Suriyavathana M,DOI: 10.24214/IJGHC/HC/7/3/320-327

Research on natural drugs has popularity due to base on discovering of bioactive compound. The antioxidant property present in the plants are one of the mechanism to observe the effect of plant compound. Antioxidant are capably to reduce the free radical effect which consist of singlet electron on the shell. Pisonia alba plant belongs to Nyctaginaceae family had the abundant healing property. This study aim to elaborate the radical scavenging activity (RSA) of Pisonia alba leaves extract. The RSA was assessed with three different extractions (ethanol, methanol and aqueous) by 5 different methods at various concentration (20 – 100 µg/ml): DPPH, FRAP, Superoxide radical, Nitric oxide and Reducing power, Vitamin C (ascorbic acid) used as positive control. ELEPA showed the RSA power when compared with MLEPA and ALEPA. The Percent inhibition scavenging activity of ELEPA with ascorbic acid on various RSA viz of  DPPH at 91±2.7 at 100 µg/ml; 90±2.2 µg/ml in FRAP; 89±2.1 µg/ml in Nitric oxide; 79±2.1 at100 µg/ml in superoxide; absorbance at 700nm in reducing power 0.721±0.015). Among the three fractions ELEPA has lowest IC50 value which strongly represents the highest scavenging power.">

Clinical Comparative Study on Efficacy of Gudadya Gutika and Punarnava Mandura in Iron Deficiency Anaemia W.S.R. Pandu

Vinaya Vishnumurthy Yaji, Vijay B. Negalur, SandeshKumar, Nagraj G Bhat,DOI: 10.24214/IJGHC/HC/7/3/30919

To study the concept of   Nutritional iron deficiency anemia w.s.r. Pandu.To evaluate the effect of Gudadyagutika in Nutritional iron deficiency anaemiaw.s.rPandu. To compare the effect of Gudadyagutika and PunarnavaMandura in Nutritional iron deficiency anaemiaw.s.r. Pandu. Single blind controlled comparative study with pre-test and post-test design.  40 subjects of iron deficiency anemia fulfilling the diagnostic and inclusion criteria were selected from the OPD and IPD of S.D.M. Ayurveda College and Hospital Udupi. Data is collected based on subjective and objective criteria of the study.Group A-In this group Gudadyagutika is administered to patients with the dose of 2-0-2 after food with anupanasukhoshnajalafor 45 days.Group B-Patients of this group given Punarnavadimandura 2-0-2 after food with anupanatakrafor 45 days.Both groups shows improvements in subjective and objective parameters, when compared, Group1 (Gudadyagutika) shows better improvements than compare to Group 2(Punarnavamandura) with statistically highly significant results in subjective and objective parameters. In this study it has shown better result in improving the Objective parameters like Haemoglobin% and improvement in decreasing the values of lymphocytes, eosinophils and in subjective parameters- improvement seen in Mandagni (reduced appetite), Durbalata(weakness), Shrama(tiredness), Pindikodvesta, Exertional dyspnoea, General fatigue, Skin pallor, Headache, Insomnia.