Research Paper in Herbal Chemistry

An Ethnobotanical Survey of Indigenous Medicinal Plants in Sarguja District, Chhattisgarh (India)

Dr. Mantosh Kumar Sinha,DOI: 10.24214/IJGHC/HC/7/3/30108

Surguja district lies in the northern part of Chhattisgarh state is biodiversity rich area, dominated by tribal communities. The major tribes of Surguja region are Nagesiya, Baiga, Kanwar, Panika, Korwa and Uraon. Uraon is one of the dominating populations amongst all the tribes found in Surguja. In Surguja, the tribal's are 55.4% of the total population. The total forest area in the region is 18,188.44 constitute 44% of the total area of the district. Recently Ethnomedicinal studies have gained importance during recent years. However, this valuable source of knowledge is not adequately documented,which impedes their widespread use, evaluation and validation.Here,in the present work selected medicinal plant species, used extensively by local people and tribal communities residing in Surguja district have been screened qualitatively to find out their ethno medicinal properties. These plants are commonly used in vomiting, diarrhea, ringworm, ear pain, gastric problem, stone, infertility, diabetes and blood pressure, Bone fracture, Bad Breath Bronchitis, Body pain,  Burns, Blood  Cancer, Cough, etc. The present work listing includes botanical name, family and ethno medicinal uses of some plants. This work highlights updated information that may provide incentive for proper evaluation of the plants medicinal agent against many human diseases.

Clinical Comparative Study on Efficacy of Gudadya Gutika and Punarnava Mandura in Iron Deficiency Anaemia W.S.R. Pandu

Vinaya Vishnumurthy Yaji, Vijay B. Negalur, SandeshKumar, Nagraj G Bhat,DOI: 10.24214/IJGHC/HC/7/3/30919

To study the concept of   Nutritional iron deficiency anemia w.s.r. Pandu.To evaluate the effect of Gudadyagutika in Nutritional iron deficiency anaemiaw.s.rPandu. To compare the effect of Gudadyagutika and PunarnavaMandura in Nutritional iron deficiency anaemiaw.s.r. Pandu. Single blind controlled comparative study with pre-test and post-test design.  40 subjects of iron deficiency anemia fulfilling the diagnostic and inclusion criteria were selected from the OPD and IPD of S.D.M. Ayurveda College and Hospital Udupi. Data is collected based on subjective and objective criteria of the study.Group A-In this group Gudadyagutika is administered to patients with the dose of 2-0-2 after food with anupanasukhoshnajalafor 45 days.Group B-Patients of this group given Punarnavadimandura 2-0-2 after food with anupanatakrafor 45 days.Both groups shows improvements in subjective and objective parameters, when compared, Group1 (Gudadyagutika) shows better improvements than compare to Group 2(Punarnavamandura) with statistically highly significant results in subjective and objective parameters. In this study it has shown better result in improving the Objective parameters like Haemoglobin% and improvement in decreasing the values of lymphocytes, eosinophils and in subjective parameters- improvement seen in Mandagni (reduced appetite), Durbalata(weakness), Shrama(tiredness), Pindikodvesta, Exertional dyspnoea, General fatigue, Skin pallor, Headache, Insomnia.

Radical scavenging activity of Pisonia alba leaves in different extracts

Kavitha Rani M and Suriyavathana M,DOI: 10.24214/IJGHC/HC/7/3/320-327

Research on natural drugs has popularity due to base on discovering of bioactive compound. The antioxidant property present in the plants are one of the mechanism to observe the effect of plant compound. Antioxidant are capably to reduce the free radical effect which consist of singlet electron on the shell. Pisonia alba plant belongs to Nyctaginaceae family had the abundant healing property. This study aim to elaborate the radical scavenging activity (RSA) of Pisonia alba leaves extract. The RSA was assessed with three different extractions (ethanol, methanol and aqueous) by 5 different methods at various concentration (20 – 100 µg/ml): DPPH, FRAP, Superoxide radical, Nitric oxide and Reducing power, Vitamin C (ascorbic acid) used as positive control. ELEPA showed the RSA power when compared with MLEPA and ALEPA. The Percent inhibition scavenging activity of ELEPA with ascorbic acid on various RSA viz of  DPPH at 91±2.7 at 100 µg/ml; 90±2.2 µg/ml in FRAP; 89±2.1 µg/ml in Nitric oxide; 79±2.1 at100 µg/ml in superoxide; absorbance at 700nm in reducing power 0.721±0.015). Among the three fractions ELEPA has lowest IC50 value which strongly represents the highest scavenging power.">

Identification of Novel Metabolites and Screening of Antimicrobial and Anti-mycobacterium tuberculosis Activity of Bauhinia Purpurea Flowers

P. Sarojini, K. Shriram, M. Jeyachandran ,V. S. Krishna and D. Sriram,DOI: 10.24214/IJGHC/HC/7/3/32835

Bauhinia purpurea is a significant herb with prodigious nutritional and medicinal value. Research on its secondary metabolites and biological activities of antimicrobial, analgesic, anti-inflammatory, antidiabetic, anticancerous, anti-diarrheal and nephroprotective activity has been boundless. In the present study, the flowers of Bauhinia purpurea were exhaustively extracted with aqueous ethanol and the solvent was removed to get crude extract and it was found to be a mixture of components by TLC. The extract was analyzed for primary phytochemical tests and GCMS studies to find out the nature of compounds present in it. The occurrence of steroids, reducing sugars, saponins, xanthoproteins, tannins and flavonoids were identified from the primary phytochemical tests. From the GCMS studies, four new compounds Pelargonyl acetate, Kaempferol 3, 7-dimethyl ether, γ-Terpinene and β-Linalool were identified   from the Bauhinia purpurea flower. Furthermore, fifteen known compounds 5-Methoxy-3, 7-dihydroxyflavanone, 5-Methoxy-3, 7-dihydroxyflav- anone, Lutein and Glaucine etc., were also obtained from the above extract. The crude extract was evaluated for antimicrobial and antimycobacterium tuberculosis activity, which possessed pronounced antimicrobial and prominent antimycobacterial tuberculosis activity at 2.25 MIC µg/mL.

Harnessing the medicinal importance of Clitoria ternatea for diseases and beyond: a review of its phytochemistry and pharmacology

K. Sharma, R. Bist and ES. Chauhan,DOI: 10.24214/IJGHC/HC/7/3/33646

Clitoria ternatea L generally recognized as Butterfly pea is a traditionally being used Ayurvedic medicine. It is being utilized from centuries to enhance memory and as nootropic, anti-stress, as tranquilizer to relieve anxiety, depression, and convulsion. C. ternatea isolated secondary metabolites include triterpenoids, flavonol glycosides, anthocyanins. It possesses extensive variety of pharmacological actions like fighting against microorganisms, reducing fever, alleviating inflammation and pain, promoting diuresis, controlling diabetes and destroying insects. It is also used as a vascular smooth muscle relaxant. The current review encompasses the bio-active components, pharmacological, phytochemical and toxicity studies of C. ternatea having clinical usage in the Ayurvedic system along with a serious consideration on its future ethno pharmacological potential

Study of Antioxidant and Aldose Reductase Inhibitory Activity of a weed, Hygrophila ringens (L.) R. Br. ex (Steud.)

T. V. Ramana, O. S. Rathor1,G. Gyananath, Zeyad A. Dahan, G. B. Tiwari4, T.A. Kadam, DOI: 10.24214/IJGHC/HC/7/3/34759

Bioprospecting involves exploration of unidentified species of living organisms for the development of pharmaceuticals, botanical medicines, crop protection agents, cosmetics, horticultural and agricultural seeds, environmental monitoring, manufacturing and construction. With the popularity of bioprospecting for natural compounds, the idea is to elaborate the various chemical components on one of the uncommon plant, Hygrophila ringens (L.) R. Br. ex (Steud.) Acanthaceae family from Marathwada region. In the current study, the phytochemical components were screened in the leaves, flowers and stem of Hygrophila ringens (L.). The analysis revealed  presence of  diverse class of  compounds of therapeutic significance and as speculated the plant extracts exhibited potent antioxidant and ARI activity.  Some of the potential phytochemical compounds may have an important role in these activities.

Hepatoprotective Activity of Methanolic Stem Bark Extract of Parkinsonia aculeata L. in CCl4 Intoxicated Rats

Suneeta Rao, Anil Kumar Sharma, Rajnish Gupta, M.P. Dobhal, M.C. Sharma,DOI: 10.24214/IJGHC/HC/7/3/36068

: Present study evaluated the hepatoprotective action of Parkinsonia aculeata stem-bark methanol extract in CCl4 intoxicated rats. Animals were intraperitoneally administered with CCl4 at1 ml/kg b.wt. once a week for hepatic damage. Oral treatment with P. aculeata methanolic extract at 25, 50 and 100 mg/kg b.wt./day brought about significant normalcy in hepatic tissue injury as well as serum biochemical parameters. Outcome of present study proves the liver rejuvenation potency of P. aculeata which is also supported by strong antioxidant activity of the plant to reduce oxidative stress.

Lantana camara: Ransack of Phytochemical and Pharmacological Aspect

Shyamal K. Jash and Lalan Chandra Mandal,DOI: 10.24214/IJGHC/HC/7/3/36981

India is a gifted country with rich biodiversity and treasure of medicinal plants. From the ancient times various plants have been using for healthcare. Among them, very few were studied systematically so far. Lantana camara is a flowering ornamental and evergreen plant found throughout India. The plant has evoked a lot of interests among the researchers due to its diversified pharmaceutical potential. The Plant is reported to be used in traditional medicine system since very long time for the treatment of various ailments including itches, cuts, ulcers, swellings, bilious fever, cataract, eczema and rheumatism. In last few decades, scientists and researchers have investigated on different parts of the plants. In continuous investigations on this plant, it has been observed that various parts of the plant are used in the treatment of cold, headache, chicken pox, eye injuries, whooping cough, asthma, bronchitis and arterial hypertension. These studies established the therapeutic potential of Lantana camara in modern medicines and considered to be promising candidate for the drug discovery. The current review has deeper focus on Taxonomy, Geographical distribution, phytochemical studies, pharmacological activities and toxicology of Lantana camara.