From day to day, everyone is too busy to Manage their lives. Hence, multitasking is a common practice involved by individuals in this era. It does save our time, but does it have any impact on health, whether psychologically or physically. From physiological prospectus one can understand the concept of Mana, the entity which makes the sensory organ  to connect with their respective stimulus or  motor  organ  to take action / regulates the action of Karmendriya. Manas is the connecting link between the Atma  with Sharir  and  hence influences  both.  Mana subtlety makes it move quickly and conjugate with the sense organs so quickly that it appears as though all sensory impressions are occurring concurrently at the same moment and that it is simultaneously connected to all Indriyas. Nevertheless, it only connects to one Indriya at a time. This demonstrates its Ekatva quality. Multitask is to work on two or more tasks at once, to switch between tasks often, or to complete several jobs quickly one after the other. Here by understanding the physiology of Mana, one can understand its role in multitasking and it’s physical and psychological effect on individual. As Mana has major a role in  keeping  healthy  status  as  well  as  in  disease production

Adhatoda vasica (Vasa) leaf is a common bronchodialator in Ayurveda.  It has several quinazoline alkaloids which has high therapeutic values, especially, vasicine.  It also contains essential oils, vitamins, steroids and many fatty acids.  In this work an attempt was made to compare the effect of geographical variation in the Physico-chemical values of Adhatoda vasica leaves collected from different geographical regions of Trivandrum District, the capital of Kerala.  The study also extends to compare the quantity of vasicine content in these samples using HPTLC fingerprinting

Turmeric (Curcuma longa) has been historically celebrated for its medicinal properties, with curcumin being the primary bioactive compound studied for its anti-inflammatory and anticancer effects. However, turmeric contains a diverse array of bioactive compounds that are not curcumin, which also contribute significantly to its therapeutic efficacy. This review explores the anti-inflammatory and anticancer activities of curcumin-free components, such as essential oils (turmerones), flavonoids (quercetin, kaempferol), and polysaccharides. Through a detailed examination of these compounds' molecular mechanisms and their synergistic effects, this review highlights the emerging therapeutic potential of curcumin-free turmeric constituents in treating chronic inflammatory diseases and cancer. Furthermore, clinical and preclinical evidence supports the idea that these bioactive compounds, particularly when combined, may have enhanced therapeutic effects over curcumin alone.">

Phytochemicals, bioactive compounds derived from plants, play a significant role in health maintenance and disease prevention. Their use spans nutraceuticals, traditional medicine and functional foods due to their antioxidant, anti-inflammatory and therapeutic properties. However, ensuring the safe use of phytochemicals requires thorough understanding of their toxicity, appropriate dosages and adherence to regulatory guidelines. Dosage determination is influenced by factors such as bioavailability, therapeutic index and synergistic combinations with other compounds, aiming to achieve an optimal balance between efficacy and safety. Regulatory frameworks vary globally, with organizations like the FDA, EMA and FSSAI enforcing standards on manufacturing practices, product labeling and claims to ensure consumer safety. This abstract emphasizes the critical need for rigorous safety evaluations, accurate dosage guidelines, and comprehensive regulations to support the safe and effective use of phytochemicals in healthcare. Phytochemicals, bioactive compounds derived from plants, hold significant therapeutic potential but must be used with caution due to concerns surrounding safety, appropriate dosing and regulatory oversight. While phytochemicals offer promising benefits in disease prevention and treatment, their natural origin does not always ensure safety, as certain compounds may exhibit toxicity, allergenicity or drug interactions. Globally, the regulation of phytochemicals varies widely, with countries like the U.S, EU, and India adopting different approaches for safety monitoring and quality control. Regulatory frameworks are evolving to balance consumer access with the need for stringent safety measures. This review highlights the importance of scientific research in setting dosage guidelines and ensuring the safe, regulated use of phytochemicals in healthcare, emphasizing the need for standardization and consistent oversight across the globe.

Depressive disorder, characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in daily activities, is a prevalent and debilitating mental health condition. It affects millions globally and presents significant challenges in terms of diagnosis, treatment, and impact on quality of life. Depressive disorder can be approached as Unmaada in Ayurveda, the management based on the clinical presentation. Śodhana Cikitsa is observed as effective in depression. Marsha Nasya is being practiced in depression with several medicines such as Anuthaila, Vilwadi gulika, Ksheerabala thaila etc. and no validated data available.The study is planned with the objectives to record the existing practices of Marsha Nasya in depressive disorder during the study period and to assess the effect of Marsha Nasya in depressive disorder.10 participants satisfying ICD-10 diagnostic criteria of depression and fulfilling the inclusion criteria were selected from OPD and IPD of VPSV Ayurveda college hospital and Government Ayurveda Research Institute for Mental health and hygiene, Kottakkal. The data obtained were statistically analyzed on 0^th day and on 8^th day.While assessing Hamilton’s depression rating scale with Wilcoxon Signed Ranks Test, Marsha Nasya was found to be statistically significant at the level of < 0.01 in reducing the total score.Several types of Marsha Nasya is in practice in depression. Marsha Nasya is having a significant effect in reducing the signs and symptoms of Depressive disorder as a first line treatment.

The aim of this work is to highlight secondary metabolites, to quantify total polyphenols and to evaluate the antioxidant activity of Raphionacme daronii and Raphionacme brownii, two plants from the Apponaceae family. The gravimetric method allowed to determine the water content of the tubers, equal to 92.85% for R. daronii and 94.61% for R. brownii. Chemical screening of extracts of the tubers and the aerial part including the stems and leaves of the two plants, showed the presence of terpenes/sterols, polyphenols and flavonoids.The polyphenol and flavonoid contents were determined by spectrometric method as well as the antioxidant activity. The polyphenol contents are: 81.06 and 19.9 mg EAG/g respectively for the crude methanol extracts of the tubers and the aerial part of R. Daronii; 8.7 and 20.11 mg EAG/g respectively for the extracts of the tubers and the aerial part of R. Brownii. The IC₅₀ are: 135.7±2.132 µg/mL and 71.09±1.852 µg/mL respectively for the extract of the tubers and the aerial part of R. daronii; 336.9±2.527 µg/mL and 11.52±1.06 µg/mL for the extracts of the tubers and the aerial part of R. brownii. These results could justify the use of these two species against certain deseases.

Ayurveda has a unique concept known as polyherbalism, albeit it can be difficult to define in terms of contemporary standards. The Sarangdhar Samhita, a work of Ayurvedic literature, introduced the concept of polyherbalism to achieve better medicinal efficacy. The amount of active ingredients employed from each plant is insufficient to provide any pharmacological impact. There is evidence to suggest that crude plant extracts frequently have higher potencies than individual ingredients.Due to synergism, polyherbalism confers some benefits which are not accessible in single herbal formulations. This work is to report the method of preparation ofBiogymnema, is a novel polyherbal formulation for diabetic mellitus and to find out the active principles in the formulation responsible for the antidiabetic action. To validate the antioxidant activity of the formulation and to study the mechanism of action of the phytochemical constituents in the formulation. Biogymnema, the polyherbal formulation is made from the ethanol extract of Gymnemasylvestre, Berberis aristate, Costusspeciosa, Pterocarpus marsupium, Syzygiumcumini, Picrorrhizakurroa, Trigonella foenum, Cinnamomum verum, Alstoniascholaris, Asphaltum pure. Fingerprinting of phytochemical constituents of the antidiabetic polyherbal formulation was performed using spectroscopical (like IR and UV) and chromatographic techniques like LCMS. Biochemical assays like DPPH and SOD radical scavenging assays were done to validate its biological activity.The mode of action of phytochemical constituents against monoamine oxidase B that have a high impact on diabetes management and complication was also investigated using molecular docking. LC-MS/MS analysis of antidiabetic polyherbal formulation ethanolic extract identified 33 compounds, including the popular flavonoids and phenolic acids. Among them,9 compounds show antidiabetic activity. Besides this these compounds also shows biological activities like anticancerous, anti-inflammatory, antiaging, antiproliferative properties etc., The absorption bands in the UV spectra and harmonic vibrations in IR region indicates the presence of the phytochemicals like  carbohydrates, terpenoids, flavonoids, saponins, and alkaloids.The dosedependent response of the anti-diabetic polyherbal formulation demands 40 µg/mL concentration of drug for 50% DPPH radical scavenging and 10 µg/mL for SOD radical scavenging. The docking result points out that many of the active principles in the polyherbal formulation shows a significant binding affinity score than the inbuilt ligand, safinamide binding affinity value, the inbuilt ligand safinamide had exhibited a docking score of -9.014 with -74.785 kcal binding energy. While pulmatin showed a docking score of  -10.533 with binding energy -64.220 kcal, genistein 8-C-glucoside with a docking score of  -9.541 with binding energy -64.673 kcal and all others have a comparable docking score and binding affinity. These results points out that the polyherbal formulation is rich in antioxidant ingredients and will require less amount for high performance. The findings obtained in the present work indicate that the the novel polyherbal formulation, Biogymnema may constitute a safe multi-target remedy to treat diabetes.

Plants have been the basis for medical treatments through much of human history, and such traditional medicine and still widely practiced today. The knowledge of the healing properties of medicinal plants has been transmitted over the centuries within and among human communities. Alangium salvifolium is a deciduous shrub belongs to family Alangiaceae with a long history of traditional medicinal uses in many countries, especially in India, China and Phillipines.  Almost every part of A.salvifolium including roots, leaves, stem and bark are used in the Ayurveda and Siddha systems of medicines for the treatment of various diseases. It is reported to contain various biologically active phytochemicals such as flavonoids, saponins, glycosides, alkaloids etc. The plant has been also reported to possess antifungal activity, anti-diabetic activity, antioxidant, antimicrobial activity, anti-inflammatory activity, wound healing activity, anti-cancer activity, etc.

Male factors contribute to over 40% of infertility cases. Common causes include erectile dysfunction, ejaculatory defects, sperm abnormalities, and seminal fluid disorders. Conventional therapies have limitations, including adverse side effects. Ayurveda has documented aphrodisiac drugs that may address underlying causes and play a crucial role in managing male infertility. This review explores evidence-based data on Ayurvedic drugs for male infertility. Ayurvedic texts describe Vajikaran (aphrodisiac) drugs. Literature from electronic databases such as PubMed and Google Scholar was reviewed, covering research published up to 2023.Ayurvedic drugs contain important phyto-constituents, proven through preclinical and clinical trials. These herbs enhance male fertility by promoting spermatogenesis, reducing stress, modulating immunity, rejuvenating body systems, boosting testosterone production, and improving semen quality and motility through their action on the hypothalamus-pituitary-gonadal axis.Ayurvedic aphrodisiac drugs have a unique contribution to male infertility treatment. Their mode of action, administration, and indications vary depending on the cause and patient condition, supporting their rational use.

• Ajwain (Trachyspermum ammi (L.) sprague), also known as Bishop’s weed or Carom seed, belongs to the family Apiaceae, Ajwain (Trachyspermum ammi (L.) sprague), a native of Egypt is distributed throughout India and it is mostly cultivated in Gujarat and Rajasthan. Ajwain is an aromatic seed spice which is cultivated mainly for its seed, herb and volatile oil. Ajwain is grown in arid or partially arid regions where concentration of salts is very high. Many publications describing its nutritional and therapeutic qualities have been published in reputable scientific journals during the last few decades. The current study analyses Ajwain cultivation in two separate soil zones with varying weather conditions